Большие Мотыкалы is a village in Brest Raion, in Brest Region, Belarus. Большие Мотыкалы lies at 137 m above sea level. It has 2,986 inhabitants. The nearest city is Brest, 14.3 km to the southeast. Among the landmarks around are Brest Fortress (13.5 km), Berestye Archeological Museum (13.9 km) and Museum «Rescued Art Values» (14.1 km).

Also written Вялікія Матыкалы.