Holýšov is a town (město) in Plzeň-South District, in the Plzeň Region, Czechia. Holýšov lies at 357 m above sea level. It has 5,647 inhabitants (2024). The nearest city is Plzeň, 26 km to the northeast. Among the landmarks around are Kladruby Monastery (15.3 km), Horšovský Týn Castle (13.4 km) and Švihov Castle (18.5 km). Among the natural features are Nový Herštejn (20 km) and Kacerna oak (8.0 km).