Sepstrup is a village in Silkeborg Municipality, in the region of Central Denmark, Denmark. Sepstrup lies at 115 m above sea level. The nearest city is Silkeborg, 11.1 km to the northeast. Among the landmarks around are Museum Jorn (10.4 km), Silkeborg Museum (10.8 km) and Illerup Ådal (31 km). Among the natural features are Himmelbjerget (14.9 km) and Store Hørbyhøj (5.0 km).