Agios Nikolaos is a village in Istiaia-Aidipsos Municipality, in the regional unit of Euboea, in the region of Central Greece, Greece. Agios Nikolaos lies at 23 m above sea level, 0.6 km from the Euboea mountains. It has 74 inhabitants (2021). The nearest city is Volos, 51 km to the northwest. Beaches nearby: Agiou Nikolaou (0.2 km), Mavrikas (0.8 km), Psaropouli/Vasilikon (5.4 km). Among the landmarks around are Oreus (23 km), Saint George Monastery (26 km) and Artemision (11.0 km). Among the natural features are Ποντικονήσι Εύβοιας (3.8 km).
Also written Άγιος Νικόλαος.