Agios Nikolaos is a town in Naousa Municipality, in the regional unit of Imathia, in the region of Central Macedonia, Greece. Agios Nikolaos lies in the Vermio mountains. It has 105 inhabitants (2021). The nearest city is Veria, 17.1 km to the southeast. Among the landmarks around are Aegae (28 km), Mieza (7.3 km) and Beroea (17.3 km). Among the natural features are Edessa Waterfalls (21 km) and Kajmakčalan (41 km).

Also written Άγιος Νικόλαος.