Mikro Souli is a village in Amphipolis Municipality, in the regional unit of Serres, in the region of Central Macedonia, Greece. Mikro Souli lies in the Pangaion Hills mountains. It has 336 inhabitants (2021). The nearest city is Drama, 33 km to the northeast. Beaches nearby: Ofryniou (14 km). Among the landmarks around are Philippi (32 km), Amphipolis (11.1 km) and Eion (13.6 km). Among the natural features are Alistratis cave (16.2 km).

Also written Μικρό Σούλι.