Agios Nikolaos is a village in Nikolaos Skoufas Municipality, in the regional unit of Arta, in the region of Epirus, Greece. Agios Nikolaos lies 0.8 km from the Makrynoros mountains. It has 180 inhabitants (2021). The nearest city is Arta, 9.9 km to the northwest. Beaches nearby: Platanaki (12 km). Among the landmarks around are Ambracia (9.3 km), Church of the Parigoritissa (10.0 km) and Bridge of Arta (10.1 km). Among the natural features are Peranthi hill (6.2 km).

Also written Άγιος Νικόλαος.