Georgios Karaiskakis is a village in Mouzaki Municipality, in the regional unit of Karditsa, in the region of Thessaly, Greece. Georgios Karaiskakis lies in the Agrafa mountains. It has 416 inhabitants (2021). The nearest city is Trikala, 16.7 km to the northeast. Among the landmarks around are Monastery of Great Meteoron (34 km), Monastery of Varlaam (33 km) and Osman Shah Mosque (16.3 km). Among the natural features are Theopetra Cave (29 km).
Also written Γεώργιος Καραϊσκάκης.
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