Agios Nikolaos is a village in Agrinio Municipality, in the regional unit of Aetolia-Acarnania, in the region of West Greece, Greece. Agios Nikolaos lies in the Panaitoliko (mountain range) mountains. It has 97 inhabitants (2021). The nearest city is Agrinio, 4.7 km to the west. Among the landmarks around are Calydon (30 km), Thermos (20 km) and Stratos (13.2 km).
Also written Άγιος Νικόλαος.