Agios Nikolaos is a village in Aktio-Vonitsa Municipality, in the regional unit of Aetolia-Acarnania, in the region of West Greece, Greece. Agios Nikolaos lies in the Acarnanian mountains. It has 70 inhabitants (2021). The nearest city is Agrinio, 28 km to the east. Beaches nearby: Chioni (14 km), Agrilia (14 km). Among the landmarks around are Lefkada (36 km), Nicopolis (45 km) and Stratos (19.0 km). Among the natural features are Drakonera (29 km).

Also written Άγιος Νικόλαος.