Pypliškė is a village in Šilutė District Municipality, in Klaipėda County, Lithuania. Pypliškė lies at 35 m above sea level. It has 28 inhabitants (2021). The nearest city is Tauragė, 44 km to the east. Near the border: Russia, 23 km. Among the landmarks around are Macikai POW and GULAG camps (11.7 km), Evangelical Lutheran Church in Šilutė (15.4 km) and Synagogue Žemaičių Naumiestis (7.8 km).
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