Simaniškis is a settlement in Biržai District Municipality, in Panevėžys County, Lithuania. The nearest city is Panevėžys, 69 km to the southwest. Among the landmarks around are Church of the Assumption of Mary in Skaistkalne (10.9 km), Biržai Castle (12.3 km) and Rundāle Palace (47 km). Among the natural features are Cow cave (12.3 km) and Jurgis Bielinis oak (4.5 km).
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