Upės Sėta is a village in Biržai District Municipality, in Panevėžys County, Lithuania. Upės Sėta lies at 60 m above sea level. The nearest city is Panevėžys, 77 km to the southwest. Among the landmarks around are Church of the Assumption of Mary in Skaistkalne (21 km), Lutheran church in Ērberģe (4.8 km) and Biržai Castle (21 km).