Derazhnia is a city in Khmelnytskyi Raion, in Khmelnytskyi Oblast, Ukraine. Derazhnia lies at 215 m above sea level. It has 9,772 inhabitants (2022). The nearest city is Khmelnytskyi, 37 km to the west. Among the landmarks around are Medzhybizh Fortress (18.9 km), Jewish necropolis in Medzhybizh (19.5 km) and Letychiv Fortress (19.1 km).
Also written Деражня.