Mudryholovy is a village in Khmelnytskyi Raion, in Khmelnytskyi Oblast, Ukraine. Mudryholovy lies at 299 m above sea level. The nearest city is Khmelnytskyi, 39 km to the northeast. Among the landmarks around are Holy Intercession Church (19.1 km), Saints Peter and Paul church, Yarmolyntsi (13.0 km) and Church of the Intercession, Sharivka (21 km).

Also written Мудриголови.