Osykove is a village in Khmelnytskyi Raion, in Khmelnytskyi Oblast, Ukraine. Osykove lies at 375 m above sea level. The nearest city is Khmilnyk, 42 km to the northeast. Among the landmarks around are Medzhybizh Fortress (21 km), Jewish necropolis in Medzhybizh (22 km) and Letychiv Fortress (12.1 km).

Also written Осикове.