Plesna is a village in Shepetivka Raion, in Khmelnytskyi Oblast, Ukraine. Plesna lies at 280 m above sea level. It has 1,078 inhabitants. The nearest city is Shepetivka, 5.7 km to the northeast. Among the landmarks around are Sanguszko Palace (13.5 km), Carmelite Monastery in Horodyšče (5.2 km) and Bernardine Monastery (13.5 km).
Also written Плесна.