Agia Varvara is a village in Agrinio Municipality, in the regional unit of Aetolia-Acarnania, in the region of West Greece, Greece. Agia Varvara lies in the Panaitoliko (mountain range) mountains. It has 149 inhabitants (2021). The nearest city is Agrinio, 11.7 km to the west. Among the landmarks around are Calydon (33 km), Thermos (17.1 km) and Stratos (18.8 km).

Also written Αγία Βαρβάρα.